Howard: This is the worst cobbler I've ever eaten. It tastes like it's made of actual ground-up shoemaker.
Sheldon: Amusing. A play on the two meanings of cobbler.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Bernadette: Maybe we should get one of those machines to help her up the stairs.
Howard: You mean a forklift?

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Leonard: I'm sorry.
Raj's sister: Why do you say that?
Leonard: When I'm in bed with a girl, that's just my natural response.

Raj: Hands off my sister.
Sheldon: Why would I touch your sister? She's all covered in airplane germs.

Sheldon: And to think, I was about to waste the last of my good haemorrhoid cream on you.