Penny: Howard, would you like to explain to me why your Facebook page has a picture of me sleeping on your shoulder captioned: "Me and My Girlfriend"?
Howard: Uh oh, here comes "The Talk"!
*Penny tries to blow up Howard's head.*

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Howard: I invented a game. Want to play?
Leonard: Sure.
Howard: It's called Emily or Cinnamon. I give you actual quotes I've heard Raj say, and you guess if he was talking to his girlfriend or his dog.

Bernadette: Does your mother call you every day at work to see if you had a healthy lunch?
Howard: My mother calls me every day at work to see if I had a healthy bowel movement.

Leonard: Is this the stuff you want me to try on?
Penny: No this is the stuff I want you to throw out. Seriously, don't even give it to charity. You won't be helping anyone.

Leonard: Sheldon, we have to do this.
Sheldon: No we don't. We have to take in nourishment, expel waste, and inhale enough oxygen to keep ourselves from dying. Everything else is optional.

Sheldon: Just the latest copy of Applied Particle Physics Quarterly.
Penny: Oh, you know, that is so weird that yours came and mine didn't.