Leonard: No, absolutely not.
Sheldon: It's not a big deal.We have latex gloves.
Leonard: I don't care what the symptoms are. My girlfriend is not going to give you a prostate exam.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Stephanie: I don't see anything at all, Sheldon.
Sheldon: Well, you're the doctor, but I am constantly hearing this annoying sound.
Leonard: Me too.
Sheldon: Is it a high frequency whistle?
Leonard: No, it's more of a relentless, narcissistic drone.

Leonard: Don't you think if a woman was living with me I'd be the first one to know about it?
Penny: Oh, sweetie, you'd be the last one to know about it.

Sheldon: I trust Leonard satisfied you sexually last night.
Leonard: Oh good God! Sheldon we don't ask questions like that!
Sheldon: I heard you ask it over and over. How is it inappropriate for me to ask it once?
Stephanie: He did very nicely.
Sheldon: See? She's not offended. And now you finally have an answer.