(Howard has just told Mary about his upcoming trip to the International Space Station.)
Mary Cooper: I bet your mom is really proud of you.
Howard: Nope. She says if I don't back out, she's gonna go on a hunger strike. It'd take years before she'd be in any kind of danger, but still.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Mary Cooper: It's all themed. There's Jonah and the Whale Watching. All-you-can-eat Last Supper Buffet. And my personal favorite, Gunning with God.

Mary Cooper: I thought it was our Indians that had the occasional alcohol problem.
Leonard: We don't say that either. I'll make you list.
Mary Cooper: Oh, that'd be mighty white of you.

Mary Cooper: Lord, Mary Cooper here, coming to you from Gomorrah, California.