Leonard: Hmm, if it's yogurt that helps ladies poop, I think Raj beat you to it.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Raj: But excuse me, I have something to say. None of you may realize it, but I was very much looking forward to this weekend. It was gonna be like the old days -- the four of us hanging out, playing video games, before you guys all got girlfriends. Do you have any idea what it's like to be the only one without a girlfriend? Even if I get one someday, I'll still be the guy who got a girl after Sheldon Cooper!

Leonard: We'll miss you Sheldon.
Sheldon: Yeah, well, who wants to spend the whole weekend, running around a bunch of pretend planets, battling made up monsters? That's for babies.
Howard: Yeah, but it's got lightsabers.
Sheldon: Please, Amy! It's got lightsabers!

Howard: Look, if you don't want to go to the party, just don't go. You're a grown man. Act like one. Tell Amy you want to spend the weekend having a sleepover and playing video games with your friends!