Sheldon: Aren't you gonna come with me?
Howard: While you confront your mother about her sex life? I'd rather go back to that bar in assless chaps.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Raj: It's too late. He's been murdered by someone in this room. Welcome to another classic Koothrappali murder mystery dinner.
Amy: I'm leaving.

Sheldon: Well, this is confusing for me. But I don't want to stand in the way of your happiness. So, I will condemn you internally while maintaining an outward appearance of acceptance.
Mary: That is very Christian of you.