Howard: Ma, I'm putting you on speaker-phone with Raj's parents. Can you tell them that you're okay with me going to the Arctic?
Mrs. Wolowitz Arctic? I thought you said Arkansas.

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Mrs. Wolowitz Howard, it's the phone.
Howard: I know it's the phone, Ma. I can hear the phone.
Mrs. Wolowitz Well who's calling at this ungodly hour?
Howard: I don't know.
Mrs. Wolowitz Well ask them why they're calling at this ungodly hour.
Howard: How can I ask them when I'm talking to you?

Mrs. Wolowitz It's this dress. When I put my front in, my back pops out. When I put my back in, my front pops out. It's like trying to keep two dogs in a bathtub.
Sheldon: What do you want me to do?
Mrs. Wolowitz We're gonna have to work as a team. Get in here, grab a handful and start stuffing.

Raj: Well, I'm a Hindu. My religion teaches that if we suffer in this life we are rewarded in the next. Three months at the North Pole with Sheldon and I'm reborn as a well-hung billionaire with wings.

Leonard: Howard, this is big science. You could be the engineer who builds the equipment that puts us on the cover of magazines.
Howard: I could also be the engineer who builds the crossbow that kills Sheldon.

Sheldon: Leonard, you may be right. It appears that Penny secretly wants you in her life in a very intimate and carnal fashion.
Leonard: You really think so?
Sheldon: Of course not. Even in my sleep-deprived state, I've managed to pull off another one of my classic pranks. Bazinga!