Mrs. Wolowitz: Make up all you want. Your tuchus is not leaving this planet.

Howard: Hey, ma, can I have lamb stew for dinner?
Mrs. Wolowitz: Lamb stew? I'd have to go to the supermarket.
Howard: Please? I got a real hankering.
Mrs. Wolowitz: Oh, I can't say no to my little tushie face. I'll be back soon.

Mrs. Wolowitz Howard, there's a blonde girl, Patsy, here to see you.
Howard: Who?
Mrs. Wolowitz Okay, now she's saying it's Penny.

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Penny: Wait, what is going on?
Sheldon: In case you have forgotten, Schrodinger's cat is a thought experiment.
Penny: No, no, no, no, I didn't forget. Um, there's this cat in a box and until you open it, it's either dead or alive or both. Although, back in Nebraska, our cat got stuck in my brother's camp trunk, and we did not need to open it to know there was all kinds of dead cat in there.
Amy: Homespun stories, knowledge of physics and a bosom that defies it. You're the whole package, aren't you?

Sheldon: This will just take a moment, it's on a five and a quarter inch floppy.
Amy: A floppy disk?
Sheldon: Well, I started the list when I was nine.

Sheldon: [to Brent Spiner] You are now my mortal enemy.
Wil Wheaton: Don't worry it doesn't take up too much of your time.