Amy: Ooh, there's a cover band in the lounge.
Penny: Eh, no.
Amy: But they play Barry Manilow.
Penny: No.
Amy: But they're called Fairly Manilow.
Penny: Oh, okay.
Amy: Great!
Penny: No!

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Amy: But enough about Penny, let's talk about us. We're looking good.
Bernadette: We are.
Amy: Better than good. I mean look at you, your body's bangin'.
Bernadette: Amy!
Amy: Don't Amy me. We're always talking about how hot Penny is. Come on, scientist to scientist, how big are those hadron colliders?

Sheldon: I know the real reason you never made progress with that idea. You thought of it September 22nd, 2007. Two days later, Penny moved in and so much blood rushed to your genitals, your brain became a ghost town.

Bernadette: Guess who won a hundred dollars playing craps?
Penny: That's a dollar.
Bernadette: Guess who wildly over-tipped a cocktail waitress?