Sheldon: And if I may get serious for a moment. Hosting this show has been one crazy ride. With all its up and downs, I wouldn't give it up for the world. Except for now, when I'm giving it up.

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Sheldon: I'd like to take a moment to personally thank Dr. Amy Farrah Fowler, who you may or may not know is the first woman to co-host a flag or banner related Internet infotainment show.
Amy: Take that glass ceiling!

Leonard: You know what, this bottle was meant to celebrate an achievement. Let's make a pact. When one of us gets their first big breakthrough, we'll celebrate by opening this bottle and toasting Professor Abbott.
Howard: I love that.
Raj: Me too.
Leonard: Then, of course, rubbing our success in Sheldon's face.
Howard: Well that's the best part.

Amy: Sheldon, that was beautiful.
Sheldon: If you didn't press record-
Amy: I pressed it!