Howard: Easy. Instead of saying; 'No we don't wanna go on an NSF expedition,' say; 'No we don't wanna spend three months stuck in a cabin in the Arctic Circle with an anal nutbag!'

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Raj: Well, I'm a Hindu. My religion teaches that if we suffer in this life we are rewarded in the next. Three months at the North Pole with Sheldon and I'm reborn as a well-hung billionaire with wings.

Leonard: Howard, this is big science. You could be the engineer who builds the equipment that puts us on the cover of magazines.
Howard: I could also be the engineer who builds the crossbow that kills Sheldon.

Sheldon: Leonard, you may be right. It appears that Penny secretly wants you in her life in a very intimate and carnal fashion.
Leonard: You really think so?
Sheldon: Of course not. Even in my sleep-deprived state, I've managed to pull off another one of my classic pranks. Bazinga!