Bernadette: Howard, a girl doesn't go out with a man like you, with your looks, your fancy patter, and your tight hoochie pants if she's not expecting him to eventually make the move.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Leonard: Sometimes your movements are so lifelike I forget you are not a real boy.

Raj: Oh, you're so arrogant. If you were a super hero your name would be Captain Arrogant. And do you know what your super power would be? Arrogance.

Sheldon: Oh, Penny. Penny.
Penny: What's up?
Sheldon: Nothing. I just wanted to make Raj stop talking.