Howard: I can't believe I wasted all that money.
Leonard: Aw, and my girlfriend wouldn't let me get one. Look at my face. Do I look smug? I feel smug.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Howard: My wife came with both fun bags and money bags.

Sheldon: Penny, all my life I have been uncomfortable with the sort of physical contact that comes easily to others: handshaking, hugging, prostate exams. But I'm working on it, you know? Just recently, I had to put VapoRub on Amy's chest. A year ago, that would have been unthinkable.

Kripke: My work would suffer too if I was getting laid all the time.
Sheldon: Yes, that is the reason. My work is suffering because of all the laid I am getting.
Kripke: You lucky bastard.
Sheldon: What can I say, you know? She enjoys my genitals. I am giving them to her on a nightly basis.