Howard: That's not true. My happiness is not dependent on my best friend being miserable and alone.
Raj: Thank you.
Howard: Although, I'd be lying if I said it wasn't a little bit of a perk.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Leonard: What would you guys do if you were me?
Wolowitz: I would take Sheldon to Switzerland.
Leonard: Seriously?
Wolowitz: Absolutely. And I'd leave him there.

Sheldon: It was you. I touched you!
Penny: Happy Valentine's Day.

Sheldon: Hello.
Penny: Hello.
Sheldon: Ok, enough with the friendly banter. I believe you know why I am here.
Penny: Oh, I always figured it was to study us, discover our weaknesses, and report back to your alien overlords.
Sheldon: Yes amusing. Extraordinary intelligence might well appear extraterrestrial to you, but let me be more specific. I believe you know why I am here in the laundry room.