Amy: All right, pivoting to the big question. Bernadette, on your wedding night you'll be consummating your marriage. What do you think your first sexual position will be as husband and wife?
Bernadette: Amy, please.
Amy: Keeping in mind that whoever's on top may set the tone for the marriage.
Penny: Okay, show's over.
Amy: Hey, they may conceive a child on their wedding night. Don't you think the kid might get a kick out of knowing how it happened?
Penny: I don't care. Ask her things like are you going to take Howard's name? Not who's going to sit on who.

Amy: Okay, what is going on?
Penny: We just want you to be prepared for any surprises that could happen tomorrow.
Amy: What surprises?
Bernadette: We don't want to spoil anything, but you should know that Sheldon said he's ready to be physical.
Amy: You shut your damn mouth! You actually heard him say this?
Penny: Yes, he said he wants to do something to show you how much you mean to him.
Amy: I can't believe it. I don't know what to say.
Bernadette: Well, we're really happy for you and we know how much-
Amy: I do know what to say. Let's get me waxed!

Sheldon: Sheldon Cooper does not get lucky.
Amy: You and me both, brother.

Amy: Do you have any idea how hard it is to laugh at a knock knock joke that starts "Knock Knock Knock, Amy. Knock Knock Knock, Amy. Knock Knock Knock, Amy"?

Barry Kripke: Yes, yes, yes. He's a jolly good fellow. What time do the strippers arrive?

Raj: When I moved to America I was pretty lonely, but when I met Howard my life changed because we could be lonely together.

Wil Wheaton: Oh, Internet. This is so going all over you.