Howard: It was really nice of you to try to be happy for Leonard.
Sheldon: Thank you.
Howard: It must've killed you when I went to space.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Bernadette: Maybe we should get one of those machines to help her up the stairs.
Howard: You mean a forklift?

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Leonard: Sheldon's nervous about me leaving. Just keep an eye on him while I'm gone.
Penny: Oh, I don't know. Remember what happened when I took care of your goldfish?
Leonard: Well, flush Sheldon down the toilet and get me a new one.

Raj: Okay, I have a request to make.
Amy: And now he can talk. I want to cut open your brain and see what the heck is going on in there.

Bernadette: You know, one of the things that helped me get through Howard being in space for so long was getting married before he left.
Penny: Bernadette, sweetie, shut up.