Sheldon: Look at this. Elon Musk has a theory that we're all just characters in some advanced civilization's video game.
Leonard: So some alien kid spent his money on the asthma-and-glasses upgrade for me?
Sheldon: Well, he doesn't say it's a good game.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Bernadette: I had a plan. I kept leaving Dove bar wrappers around to explain any weight gain.
Amy: Where did you get empty Dove bar wrappers?
Bernadette: From all the Dove bars I ate! I'm pregnant! Try to keep up!

Bernadette: Do you know what? It's just a research project. The most important job in the world is gonna be raising this child. It's all I need to give my life meaning.
Penny: Oh, that's so beautiful.
Bernadette: You believe me? Oh, good. Eleven more chumps like you, I'll have the jury eating out of my hand.

Sheldon: I don't understand why I can't talk at this meeting.
Leonard: 'Cause when you talk, it enrages people.