Penny: So, what happened in Texas that was so bad?
Leonard: And before our next drive to Comic-Con, I need the name of that juice.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Leonard: [to a "smiling" Sheldon] We're here to see Koothrappali, not kill Batman.

Bernadette: Everyone's a better mom than me.
Raj: Oh, don't take it so personally, maybe your baby's just a jerk.

Amy: Well, uh, Howard and Bernadette had their baby.
Mary Cooper: (gasps) Oh, that's wonderful! Now, have they decided to raise it Jewish or regular?
Sheldon: Welcome to Texas.

Mary Cooper: Sheldon, if you're trying to prove me wrong, the tighty-whities on your head ain't changing my mind.