Leonard: Did you say something to Penny about Alex?
Sheldon: Oh, yes. Yeah, and a fat lot of good it did me. All she did was get mad at you.
Leonard: Why would you do that?
Sheldon: I needed advice about a woman. I would have asked you, but if the last few years have proven anything, it's that you cant tell a uterus from a unicycle.
Leonard: At least I know not to blab to a girl about somebody flirting with her boyfriend.
Sheldon: Good to know. Yeah, a few more helpful hints like that, you may find yourself on the Council of Ladies.

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Amy: I have a lab full of coked up monkeys with nothing to lose.

Sheldon: My father used to say that a woman is like an egg salad sandwich on a warm Texas day.
Alex: What?
Sheldon: Full of eggs and only appealing for a short time.

Alex: Is there a problem?
Sheldon: Let's not call it a problem. Let's call it an opportunity. To solve a serious problem.