Penny: Wait, wait, she's not gonna come here looking for you, is she?
Leonard: Oh, relax. She took Sheldon to the hospital to get a brain scan.
Penny: Oh my God. What happened?
Leonard: Nothing. Mother likes looking at brains and Sheldon likes getting his brain scanned.
Penny: Geez, what a fun couple.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Beverly Hofstadter: It might explain why the two of you have created an ersatz homosexual marriage to satisfy your need for intimacy.
Howard: Say what?

Leonard: She's only been here a day and a half, and I'm seriously considering alcoholism as a new career path.
Penny: Hey, I talked to her for five minutes yesterday, and I've been half bombed ever since.

Beverly Hofstadter: If you want to have intercourse with that girl, find out what kind of cologne her father wore.