Sheldon: Okay, step four. Do you see that small plastic case on my dresser?
Penny: Your dresser? Who is this?
Sheldon: It's Sheldon.
Penny: Oh, hey, Sheldon! How is San Francisco?
Sheldon: I'm not in San Francisco. I'm on a train. Were you even listening to me?
Penny: Uh, no, I was talking to my friend, but what's up?
Sheldon: What's up? I'll tell you whats up. I'm in a crisis situation, and I need you to marshal your powers of concentration, limited as they may be-

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Sheldon: She calls me moon-pie because I'm nummy-nummy and she could just eat me up.

Leonard: Well, it looks like you're caught between a rock and a crazy place.
Sheldon: I hate when that happens.

Sheldon: No one calls me Moon Pie but Meemaw.