Sheldon: I just know how much Professor Proton touched me as a child, and I feel that I owe it to him to try and touch as many children as possible.
Leonard: You should put that on your audition tape.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Sheldon: Until next week, this is Professor Proton saying, 01000010 01111001 01100101. That's "Bye" in ASCII binary, or good-binary.

Amy: Well, what was wrong with it? You know, did you find it borderline psychotic? I mean, I liked that about it, but you guys discuss.

Sheldon: Some things shouldn't be rebooted. Some things were perfect the way they were. Like the walled city of York, it was a delight. But New York? Blech.