Penny: I can't believe you've never read "Eat, Pray, Love".
Leonard: When she comes out with "Eat, Pray, Runaway from a giant boulder", I'll read it.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Bernadette: Besides, Penny and I are having a girl's night tonight.
Amy: Girls night, what does that entail?
Bernadette: Oh you know, girls get together hang out share girl talk.
Amy: I'm a girl.
Bernadette: Oh well maybe you could join us. I'll ask Penny.
Amy: No need, Penny and I are very close.
Leonard: You are?
Amy: Yes, In fact our mensies are synchronized.

Penny: Okay, help me out here. How does an archaeology professor get that good with a whip?
Howard: Maybe he took a class at the adult bookstore. That's how I learned.

Sheldon: Under normal circumstances I'd say I told you so. But, as I have told you so with such vehemence and frequency already, the phrase has lost all meaning. Therefore, I will be replacing it with the phrase, "I have informed you thusly".