Mrs. Wolowitz: Howard, answer the door! I'm busy!
Howard: I'm busy too. You answer it.
Mrs. Wolowitz: I can't! I'm on the toilet!
Howard: For God's sake, I don't need to hear that! Can't you just say, "I'm busy"?
Mrs. Wolowitz: I said I'm busy, but that wasn't good enough for you!
Howard: You know what? I hope it's one of those home invasion deals, and they shoot me in the head.
Mrs. Wolowitz: Well, if it's a home invader, don't tell them I'm on the toilet!

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Mrs. Wolowitz Howard, it's the phone.
Howard: I know it's the phone, Ma. I can hear the phone.
Mrs. Wolowitz Well who's calling at this ungodly hour?
Howard: I don't know.
Mrs. Wolowitz Well ask them why they're calling at this ungodly hour.
Howard: How can I ask them when I'm talking to you?

Mrs. Wolowitz It's this dress. When I put my front in, my back pops out. When I put my back in, my front pops out. It's like trying to keep two dogs in a bathtub.
Sheldon: What do you want me to do?
Mrs. Wolowitz We're gonna have to work as a team. Get in here, grab a handful and start stuffing.

Sheldon: Stop it both of you! All this fighting, I might as well be back with my parents!
*Imitating his Mom* Dammit, George! I told you if you didn't quit drinking I would leave you!
*Imitating his Dad* Well, I guess that makes you a liar, because I'm drunk as hell and you are still here!
*Imitating his Mom* Stop yelling, you're making Sheldon cry!
*Imitating his Dad* I'll tell you what is making Sheldon cry, that I let you name him SHELDON!

Sheldon: You can't make a half sandwich. If it's not half of a whole sandwich, it's just a small sandwich.

Sheldon: Leonard, when that woman moved in three years ago I told you not to talk to her, and now look. We're going to be late for the movies.