Howard: You have hypo-allergenic detergent?
Bernadette: No.
Howard: Better put it on the list. If you wash my underwear with regular soap, I get little red bumps on my tuchus.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Mrs. Wolowitz: Who's there? Are you a sex criminal?
Howard: Sex criminals don't have key, ma!
Mrs. Wolowitz: Where were you so late?
Howard: I was out with Bernadette
Mrs. Wolowitz: I know what that means, I watch Dr. Phil. I hope to God you used a condom.
Howard: I am not having this conversation with you, ma.
Mrs. Wolowitz: God forbid you get one of them fancy sex diseases.
Howard: Nobody has a disease!
Mrs. Wolowitz:I hope not. I share a toilet with you. Is that what you want, to give your mother herpes?

Amy: So, you feeling better?
Penny: Not really.
Amy: Sheldon, you have a guest who's upset.
Sheldon: I'll make tea.
Penny: Sweetie, it's OK. I don't want tea.
Sheldon: It's not optional.

Sheldon: Priya, if you're experiencing any tension or awkwardness, it may stem from the fact that Leonard and Penny used to, if I might quote Howard, "Do the dance with no pants".