Bernadette: Oh, I take pacts very seriously. One time at my lab, a petri dish of genetically modified super-virus went missing. That day we made a pinky swear never to admit we crossed Ebola with the common cold.
Howard: Why the hell would you cross Ebola with the common cold?
Bernadette: We never did. That would be a terrible, terrible thing.

Bernadette: I had a plan. I kept leaving Dove bar wrappers around to explain any weight gain.
Amy: Where did you get empty Dove bar wrappers?
Bernadette: From all the Dove bars I ate! I'm pregnant! Try to keep up!

Stuart: Oh, so she's good enough for Howard but not for me?
Howard: Yeah.
Bernadette: Yeah. Go have weird relationships with your own mother and cousin. This is his turf.

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Amy's Mom: It's nice to meet you too Sheldon, I honestly didn't believe Amy when she told me she had a boyfriend.
Sheldon: I assure you, I am quite real and I'm having regular intercourse with your daughter.
Amy's Mom: What?
Sheldon: Oh yes, We're like wild animals in heat. It's a wonder neither of us has been hurt!
Amy's Mom: Amy? What is he saying?
Amy: You wanted me to have a boyfriend, mother, well here he is! Have to sign off now. My hunger for Sheldon is stirring in my loins.
Sheldon: Oh yes. It's time for me to make love to your daughter's vagina.

Sheldon: We no longer live at 2311 Los Robles. We live at 311 Los Robles. [holds up number 2 fixture]
Leonard: You changed the address on the building? What about mail?
Sheldon: No worries. I explained our predicament to our letter carrier. He was sympathetic. His exact words were, "Got your back, Jack. Bitches be crazy."