Penny: How's your life?
Amy: Like everybody else's, subject to entropy, decay and eventual death. Thank you for asking.

Amy: Okay, what is going on?
Penny: We just want you to be prepared for any surprises that could happen tomorrow.
Amy: What surprises?
Bernadette: We don't want to spoil anything, but you should know that Sheldon said he's ready to be physical.
Amy: You shut your damn mouth! You actually heard him say this?
Penny: Yes, he said he wants to do something to show you how much you mean to him.
Amy: I can't believe it. I don't know what to say.
Bernadette: Well, we're really happy for you and we know how much-
Amy: I do know what to say. Let's get me waxed!

Sheldon: Sheldon Cooper does not get lucky.
Amy: You and me both, brother.

Amy: Do you have any idea how hard it is to laugh at a knock knock joke that starts "Knock Knock Knock, Amy. Knock Knock Knock, Amy. Knock Knock Knock, Amy"?

Mary Cooper: Now, when you said on the phone he broke up with a girl, you meant an actual girl? Not something you kids whipped up in a lab?

Howard: On the potty, what are you five?
Raj: It's a potty, what do you call it?
Howard: A toilet.
Raj: That's a little vulgar for the dinner table, don't you think?
Howard: And potty is okay?
Raj: Potty is innocent. Potty is adorable.
Howard: What do you do on the potty, wee-wee?
Raj: If I don't have to boom-boom.

Sheldon: I'd like you to meet Oppenheimer, Frisch, Panofsky, Feynman, Weisskopf.
Mary: Yeah, I get it. You got a lot of cats, and you gave 'em cute Jewish names.