Mary: He gets his temper from his daddy.
Leonard: Ah!
Mary: He's got my eyes.
Leonard: I see!
Mary: All that science stuff, that comes from Jesus.

Mary Cooper: I'm sorry, did I start that sentence with the words, "If it pleases your highness?"

Mary Cooper: You don't hunt, do you?

Sheldon: I read an article about Japanese scientists who inserted DNA from luminous jelly fish into other animals; and I thought "Hey! Fish night-lights".
Leonard: Fish night-lights.
Sheldon: It's a billion dollar idea, ssh!

Mary Cooper: Honey, why did you get a loom?
Sheldon: Well, I was working with luminous fish and I thought, hey, loom.

Mary Cooper: Dr. Gablehouser, are you busy?
Dr. Gablehouser: Well, actually-
Mary Cooper: Sheldon, he's just doodlin'. Get in here.

Wolowitz: Whaddup science bitches?

Penny: I always say that when one door closes, another one opens.
Sheldon: No it doesn't. Not unless the two doors are connected by relays or there are motion sensors involved. Or if the first door closing creates a change of air pressure that acts upon the second door.
Penny: Never mind.

Sheldon: There wouldn't have been any ass kickings if that stupid death ray had worked.

Leonard: Howard brought a date?
Sheldon: A more plausible explanation is that his work in robotics has made an amazing leap forward.

Mary Cooper: Sweetheart, your little friend is concerned about you.

Sheldon: The thing about tomatoes, I think you will really enjoy this, is that they are shelved with the vegetables but they are technically a fruit.
Penny: Interesting.
Sheldon: Isn't it!
Penny: No, I mean what you find enjoyable.

Mary Cooper: Sheldon's like a baby deer, you gotta let him come to you.

Mary Cooper: You know, you two make a cute couple.
Leonard: No, no we're not, we're not a couple, we're single, two singles, like those individually wrapped slices of cheese that are friends.
Mary Cooper: Did I pluck a nerve there?
Howard: Oh yeah.

Dr. Gablehauser: Now that's impossible, you must have had him when you were a teenager.
Mary Cooper: Oh, aren't you sweet. His father's dead.

Sheldon: I'm taking a sabbatical because I won't kowtow to mediocre minds.
Penny: So you got canned, huh?
Sheldon: Theoretical physicists do not get 'canned'. But yeah.

Mary Cooper: I remember one summer when he was thirteen, he made a small nuclear reactor in the shed and told everybody he was going to provide free electricity for the whole town. Well, the only problem was he had no - what you call - fissionable materials. Anyway, when he went on the Internets to get some, a man from the government came by and sat him down - real gentle - and told him it's against the law to have yellowcake uranium in a shed.

Sheldon: Oh boy.
Penny: What now?
Sheldon: Well, while there's some value to taking multivitamins, the human body can only absorb so much. What you're buying here are the ingredients for very expensive urine.
Penny: Well, maybe that's what I was going for.
Sheldon: Well, then you would want some manganese.

Mary: Leonard, the Lord never gives us more than we can handle. Thankfully, He blessed me with two other children who are dumb as soup.

Sheldon: The last department party, Professor Finkleday cornered me and talked about spelunking for 45 minutes.
Leonard: Yes, I was there.
Sheldon: You know what's interesting about caves, Leonard?
Leonard: What?
Sheldon: Nothing!

Mary Cooper: Leonard, don't trouble yourself. He's stubborn. He may stay in there 'til the rapture.

Mary Cooper: You know we have an Indian gentleman at the church. Dr. Patel. It's a beautiful story. The Lord spoke to him and moved him to give us all 20% off on Lasek. You know those that needed it.

Mary Cooper: Now let's get crackin'. Shower. Shirt. Shoes. And let's shove off.

Mary Cooper: I tell you, I love that boy to death but he has been difficult since he fell outta me at the K-Mart.

Sheldon: I can't believe he fired me.
Leonard: Well, you did call him a "glorified high school science teacher whose last successful experiment was lighting his own farts."
Sheldon: In my defense, I prefaced that with, "with all due respect."

Mary: I made chicken. I hope it's not one of the animals that you people think is magic.

Sheldon: You know, I've been thinking about time travel again.
Leonard: Why, did you hit a roadblock with invisibility?
Sheldon: Put it on the back burner.

Leonard: He sounds like a wise man.
Mary Cooper: Oh, not that wise. He once tried to fight a bobcat for some licorice.

Mary Cooper: Now, after a moment of silent meditation, I'm going to end with "In Jesus name". Now you two, don't feel under any obligation to join in. Unless, of course, the Holy Spirit moves you.

Raj: You can't find a bagel in Mumbai to save your life.

Mary Cooper: You have to take your time with Sheldon. His father, God rest his soul, always used to say to me "Mary, you have to take your time with Sheldon."

Mary Cooper: Everybody grab a plate and a pretty place-mat that Shelly wove.

Penny: Well what happened?
Mary Cooper: The poor boy had a fit. Locked himself in his room and built a sonic death ray.
Leonard: A death ray?
Mary Cooper: Well, that's what he called it. It didn't even slow down the neighbor kids. It pissed our dog off to no end.

Mary Cooper: You know how your daddy used to say that you could only fish for so long before you gotta throw a stick of dynamite in the water?

Penny: This is the best cobbler I've ever had.
Mary Cooper: It was always Sheldon's favorite. You know what the secret ingredient is?
Penny: Love?
Mary Cooper: Lard.

Mary Cooper: Good morning, snickerdoodle. Well that looks awful fancy, what is that?
Sheldon: It's my idea of what DNA would look like in a silicon-based life-form.
Mary Cooper: But intelligently designed by a creator, right?

Howard: Forgive me for being so bold, but I now see where Sheldon gets his charming good looks.
Mary: Honey, that ain't gonna work, but you keep trying.