Mary: He gets his temper from his daddy.
Leonard: Ah.
Mary: He's got my eyes.
Leonard: I see.
Mary: All that science stuff, that comes from Jesus.

Mary Cooper: You don't hunt, do you?

Mary Cooper: I'm sorry, did I start that sentence with the words, "If it pleases your highness?"

Sheldon: I read an article about Japanese scientists who inserted DNA from luminous jelly fish into other animals; and I thought "Hey! Fish night-lights".
Leonard: Fish night-lights.
Sheldon: It's a billion dollar idea, ssh!

Mary Cooper: Honey, why did you get a loom?
Sheldon: Well, I was working with luminous fish and I thought, hey, loom.

Mary Cooper: Dr. Gablehouser, are you busy?
Dr. Gablehouser: Well, actually-
Mary Cooper: Sheldon, he's just doodlin'. Get in here.

Wolowitz: Whaddup science bitches?

Penny: I always say that when one door closes, another one opens.
Sheldon: No it doesn't. Not unless the two doors are connected by relays or there are motion sensors involved. Or if the first door closing creates a change of air pressure that acts upon the second door.
Penny: Never mind.

Leonard: Howard brought a date?
Sheldon: A more plausible explanation is that his work in robotics has made an amazing leap forward.

Sheldon: There wouldn't have been any ass kickings if that stupid death ray had worked.

Mary Cooper: Sweetheart, your little friend is concerned about you.

Sheldon: The thing about tomatoes, I think you will really enjoy this, is that they are shelved with the vegetables but they are technically a fruit.
Penny: Interesting.
Sheldon: Isn't it!
Penny: No, I mean what you find enjoyable.

Mary Cooper: Sheldon's like a baby deer, you gotta let him come to you.

Mary Cooper: You know, you two make a cute couple.
Leonard: No, no we're not, we're not a couple, we're single, two singles, like those individually wrapped slices of cheese that are friends.
Mary Cooper: Did I pluck a nerve there?
Howard: Oh yeah.

Sheldon: I'm taking a sabbatical because I won't kowtow to mediocre minds.
Penny: So you got canned, huh?
Sheldon: Theoretical physicists do not get 'canned'. But yeah.