Sheldon: I would have been here sooner but the bus kept stopping for other people to get on it.

Leonard: You call that a glow stick? *Pulls out a Lightsaber* That is a glow stick!

Penny: Sheldon, that's not what girlfriends are for. Although you don't use them for what they're for, so what do I know?

Raj: They don't call me Brown Dynamite for nothin'.

Astronaut Mike Massimino: No problem, Froot Loops.

Penny: Oh, good, your power's out, too.
Leonard: Why is that good?
Penny: Because last month, I sent the electric company a Starbucks gift card, an apology note, and a few snapshots of me in a bra.

Sheldon: Wine and a girl in the dark. He's going to be bored out of his mind.

Sheldon: To amend the words of Toy Story, you have not got a friend in me.

Howard: You can't do "Buzz." Buzz is taken.
Raj: Buzz Lightyear is not real.
Howard: No, that's not what I'm talking about.
Raj: Well, are you talking about when he thought he was real?
Howard: No.

Leonard: Oh, great! I get to spend another night in front of our apartment dressed like one of the Village People.
Sheldon: You make that joke every three months and I still don't get it.

Sheldon: Rise and shine sleepy head, half the town probably is dead.

Sheldon: It took me a gallon of urine to get that water!

Sheldon: You're my girlfriend and you're not going to cater to my every need? Where'd the magic go?

Howard: I got pretty exciting NASA news today. Next week I fly to Houston for orientation and zero-gravity elimination drills.
Penny: What does that mean?
Bernadette: He's gonna to learn to poop in space.
Howard: Open the pod bay doors, HAL.
Raj: Maybe your nickname should be "Brown Dynamite."

Mrs Wolowitz: Howard, your Froot Loops are getting soggy!