Bernadette: Howard, we both know you can't keep up this pace. By this afternoon you're gonna be passed out on the couch and I'm gonna have three exhausted babies to deal with.

Bernadette: She's just being nice.
Howard: Well, I'm her son, how come she doesn't send someone to check on me if I'm lonely.
Bernadette: Because you have a wife!
Howard: Yeah, well, sometimes you work late.

Howard: My arm is feeling numb. *Howard rubs his right arm*
Bernadette: That's the wrong arm for a heart-attack, doofus.
*Howard switches to his left arm*

Bernadette: You better find my husband's mother, 'cause one way or another we're walking out of this airport with a dead woman.

Leonard: Do you guys have a location yet? 'Cause you don't have a lot of time.
Amy: Hey, it took us nine months to pick a date, and a week to decide if brains can have lips on them, so get in the boat and row.

Howard: Honestly, it's gonna be hard when we both go back to work. I've been thinking maybe it would be better if one of us decided to stay home.
Raj: I don't know, I was raised by servants, and look at me.
Howard: I literally can't tell if you think that's good or bad.

Sheldon: You know, I'm really happy with our wedding date. The month squared equals the square of the sum of the members of the set of prime factors of the day. Isn't that romantic?
Amy: Yes, it's like that Shakespeare sonnet, "Shall I compare thee to a day that's also a really weird math problem."