Sheldon: My brother.
Amy: Wait a minute. You didn't invite your brother to your own wedding?
Sheldon: He tormented me my whole childhood. I don't think I should reward that type of behavior with a slice of wedding cake in the shape of the Millennium Falcon.
Amy: Try again.
Sheldon: A slice of wedding cake in the shape of a cake.

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Georgie: After all my sacrifices, guess which kid my mom is the most proud of?
Leonard: If it makes you feel any better, my mom's most proud of Sheldon, too.

Georgie: Picking on him? Is that what he told you?
Leonard: Well, what about the time you threw away his Halloween costume?
Georgie: Well, yeah, 'cause he was gonna dress as some girl scientist.
Leonard: Madame Curie?
Georgie: Oh, I didn't know she was a madam.

Sheldon: Oh, maybe it's fine if she doesn't come to the wedding. I've got Amy now, and she can do everything a mom can do and more.
Leonard: Say that to her on the wedding night. Really spice things up.