Bernadette: I'm just saying. She went to college. She's really smart.
Penny: Well, I'm smarter than Karen. I can read the word "Penny" on a cup of yogurt.
Bernadette: Why are you getting so upset? I'm agreeing with you. This is a big job, and I need someone who's up to it.
Penny: I am up to it. I'm just nervous about it.
Bernadette: I know. And that's why I don't want to pressure you into doing something that you clearly don't want to do.
Penny: I know what you're up to.
Bernadette: Is it working?
Penny: Yes.
Bernadette: So I'll see you Monday morning?
Penny: Yes.
Bernadette: I bet I can make that girl president.

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Sheldon: Oh, but don't worry. I won't do that to you.
Amy: Maybe you should.
Sheldon: What?
Amy: This has been your lifelong dream. And you may not get another chance. I don't want to be the reason that you don't win a Nobel.
Sheldon: You're the only reason I deserve one.

Bernadette: Look at Howard. He was a disaster when I met him. Now he's a foxy astronaut with a hot wife.
Raj: Wait, he always wanted to be an astronaut.
Bernadette: He thinks that, too. That's how good I am.

Penny: No, it's not that.
Bernadette: Then why?
Penny: Honestly, I don't know if I'm up to it. You know, the last project I managed was my high school yearbook.
Bernadette: And?
Penny: And that was the year we didn't have one. - And? And that was the year we didn't have one. Apparently, the printers won't make them without getting paid.
Bernadette: What happened to the money?
Penny: Uh, if I didn't know then, I'm not going to magically know now.