Howard: How about computers? You like computers?
Bernadette: I use them, I don't like them.

Bernadette: She's just being nice.
Howard: Well, I'm her son, how come she doesn't send someone to check on me if I'm lonely.
Bernadette: Because you have a wife!
Howard: Yeah, well, sometimes you work late.

Howard: My arm is feeling numb. *Howard rubs his right arm*
Bernadette: That's the wrong arm for a heart-attack, doofus.
*Howard switches to his left arm*

Bernadette: You better find my husband's mother, 'cause one way or another we're walking out of this airport with a dead woman.

Bernadette: Does your mother call you every day at work to see if you had a healthy lunch?
Howard: My mother calls me every day at work to see if I had a healthy bowel movement.

Wil Wheaton: Game over, Moonpie.

Wolowitz: Puppies, how do you stand on puppies?
Bernadette: A puppy once bit my face!
Wolowitz: Of course it did.