Mary Cooper: Now, when you said on the phone he broke up with a girl, you meant an actual girl? Not something you kids whipped up in a lab?

Amy: Well, uh, Howard and Bernadette had their baby.
Mary Cooper: (gasps) Oh, that's wonderful! Now, have they decided to raise it Jewish or regular?
Sheldon: Welcome to Texas.

Mary: He gets his temper from his daddy.
Leonard: Ah!
Mary: He's got my eyes.
Leonard: I see!
Mary: All that science stuff, that comes from Jesus.

Mary Cooper: When your mom gets back, I'm gonna need to apologize for the way I spoke to her.
Penny: Well, come on, she did kinda start it.
Mary Cooper: Doesn't matter. A good Christian would have turned the other cheek. On the other hand, a good Texan would have shot her, so I'll just split the difference.

Howard: On the potty, what are you five?
Raj: It's a potty, what do you call it?
Howard: A toilet.
Raj: That's a little vulgar for the dinner table, don't you think?
Howard: And potty is okay?
Raj: Potty is innocent. Potty is adorable.
Howard: What do you do on the potty, wee-wee?
Raj: If I don't have to boom-boom.

Sheldon: I'd like you to meet Oppenheimer, Frisch, Panofsky, Feynman, Weisskopf.
Mary: Yeah, I get it. You got a lot of cats, and you gave 'em cute Jewish names.

Penny: How's your life?
Amy: Like everybody else's, subject to entropy, decay and eventual death. Thank you for asking.