Bernadette: Fine, what is it?
Howard: It's to help re-open the Comic Book Store.
Bernadette: Nope.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Howard: You know, when I was a kid I loved going there but I could never get a ride.
Raj: Ooh, what if we got a van and drove around, and picked kids up?
Sheldon: Nice! Like at parks and schools.
Howard: Toy stores, puppet shows.
Leonard: Hold on, so your idea is to get a van and cruise the streets looking for kids to pick up?
Sheldon: Yes!
Leonard: And are you going to use candy to lure them in?
Raj: We are now!

Sheldon: I have some odd freckles on my buttocks. Can I make an appointment for you to look at them?
Emily: Erm, okay, I guess.
Amy: I'm with him three years, nothing. She's with him two minutes and he's taking his pants off.

Amy: Can you see how a grown man and accomplished scientist who invests in a store that sells picture books about flying men in colorful underwear might be wasting both his financial and intellectual resources?
Sheldon: No.
Amy: Then I think it's a terrific idea.
Sheldon: Great! Wait until you hear about our van.