Sheldon: A hush falls over the crowd as Cooper studies the board. He makes his move. He's dividing both sides by I. He's adding back the coefficient. He has a value for P. He's plugging that back in. He takes the derivative, and he solves the equation. The crowd goes wild. Nobel! Nobel!

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Howard: My wife came with both fun bags and money bags.

Sheldon: Penny, all my life I have been uncomfortable with the sort of physical contact that comes easily to others: handshaking, hugging, prostate exams. But I'm working on it, you know? Just recently, I had to put VapoRub on Amy's chest. A year ago, that would have been unthinkable.

Kripke: My work would suffer too if I was getting laid all the time.
Sheldon: Yes, that is the reason. My work is suffering because of all the laid I am getting.
Kripke: You lucky bastard.
Sheldon: What can I say, you know? She enjoys my genitals. I am giving them to her on a nightly basis.