Beverly Hofstadter: Sheldon, I know the future holds great things for you, and we all can't wait to see what they are. Happy birthday, dear.

Leonard: Well, uh, okay, um, I dont want to get back together with Penny. We tried it, it was crazy, it didn't work, but I can't deal with the fact that she slept with my friend Raj. And then I find out that Raj's sister Priya, who I've been going out with for eight months, is moving back to India. So I'm just completely confused and alone.
Beverly Hofstadter: I understand.
Leonard: Got any advice?
Beverly Hofstadter: Yes. Buck up.
Leonard: Excuse me. You're a world-renowned expert in parenting and child development, and all you've got is buck up?
Beverly Hofstadter: Sorry. Buck up, sissy pants.

Beverly Hofstadter: So, Howard, have you and Rajesh finally summoned the courage to express your latent homosexual feelings towards one another?

Beverly Hofstadter: She doesn't have much in the way of career prospects, and don't make her responsible for her own orgasms as well.

Penny: So what's going on?
Sheldon: I don't know. I looked around the room, and I saw all the faces and the presents, and it it was just too much.
Penny: I get that. Hey, you want to just bring a few people in here? You know, Wil Wheaton in the bathtub, Batman on the toilet. It'll be like the weirdest Comic-Con ever.

Sheldon: I don't think I can go back out there.
Penny: That's fine. You know, I hate that your sister and her friends used to torture you. But what I hate even more is, if I was there, I would have tortured you, too.
Sheldon: Based on this pep talk, I'd say you're still doing it.
Penny: My point is, there was a time I never would've been friends with someone like you, and now you are one of my favorite people. So, if what you need is to spend your birthday in a bathroom, I'm happy to do it with you.
Sheldon: Well, everyone will think I'm weird.
Penny: Sweetie, you are weird. Everyone knows you're weird, but they're all still here because they care about you so much.

Leslie Winkle: Uh, in the past, I would've said something obnoxious, like, "Happy birthday, dumbass". But I'm not gonna do it. You and I have both grown a lot, and it's just so nice to see you all again. So happy birthday, Sheldon.
Sheldon: Oh. Oh, now, you know I hate change. Say it.
Leslie Winkle: Happy birthday, dumbass!