Leonard: I just know the longer we wait to talk about it, the weirder it gets.
Penny: Sweetie, can I just be the girl tonight?
Leonard: Absolutely. You're the girl, I'm the guy. Now, you watch your football game while I make you a little plate here.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Amy: If Sheldon proposed to me during sex, my ovaries would grab onto him and never let go.

Sheldon: Amy, when I look in your eyes and you're looking back in mine, everything feels not quite normal. Because I feel stronger and weaker at the same time. I feel excited and, at the same time, terrified. The truth is, I don't know what I feel, except I know what kind of man I want to be.
Amy: Sheldon, that was beautiful.
Sheldon: I should hope so, that's from the first Spider-Man movie.
Amy: I'll take it.