Sheldon: Leonard, I had no idea your siblings were so much more successful than you.
Raj: Yeah, you're like the Jar Jar Binks of the Hofstadter family.
Howard: Oh, meesa think yousa lookin so, so sad.
Leonard: You know, rather than mock me, my friends might realize that this is difficult and try to help me through it.
Raj: Nope, I think mocking you is more fun.
Howard: Next time, don't yousa bring mama to work. Okee-day?

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Beverly Hofstadter: It might explain why the two of you have created an ersatz homosexual marriage to satisfy your need for intimacy.
Howard: Say what?

Leonard: She's only been here a day and a half, and I'm seriously considering alcoholism as a new career path.
Penny: Hey, I talked to her for five minutes yesterday, and I've been half bombed ever since.

Beverly Hofstadter: If you want to have intercourse with that girl, find out what kind of cologne her father wore.