Howard: You're really quiet. Is everything okay?
Bernadette: Fine. Just a little tired.
Howard: I hope not too tired, because I'm feeling particularly masculine right now. All systems go, if you catch my drift.
Bernadette: I always catch your drift.

Bernadette: I had a plan. I kept leaving Dove bar wrappers around to explain any weight gain.
Amy: Where did you get empty Dove bar wrappers?
Bernadette: From all the Dove bars I ate! I'm pregnant! Try to keep up!

Stuart: Oh, so she's good enough for Howard but not for me?
Howard: Yeah.
Bernadette: Yeah. Go have weird relationships with your own mother and cousin. This is his turf.

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Penny: Wait, what is going on?
Sheldon: In case you have forgotten, Schrodinger's cat is a thought experiment.
Penny: No, no, no, no, I didn't forget. Um, there's this cat in a box and until you open it, it's either dead or alive or both. Although, back in Nebraska, our cat got stuck in my brother's camp trunk, and we did not need to open it to know there was all kinds of dead cat in there.
Amy: Homespun stories, knowledge of physics and a bosom that defies it. You're the whole package, aren't you?

Sheldon: This will just take a moment, it's on a five and a quarter inch floppy.
Amy: A floppy disk?
Sheldon: Well, I started the list when I was nine.

Sheldon: [to Brent Spiner] You are now my mortal enemy.
Wil Wheaton: Don't worry it doesn't take up too much of your time.