Wil Wheaton: You come face to face with a massive monster with a gaping maw full of teeth, three huge legs, and flailing tentacles. What do you do?
William Shatner: Fellas, it looks like we're facing a, an otyugh. Here's the plan-
Kareem Abdul-Jabbar: Hold on there, Bill.
William Shatner: Now what, Kareem?
Kareem Abdul-Jabbar: How do we know it's not a Neo-otyugh?
William Shatner: Same way I know the difference between an owlbear and a bugbear. Does that answer your question?
Kareem Abdul-Jabbar: No.
Joe Manganiello: Look, there's one way to settle this: we chop it up and look at the pieces.
Kevin Smith: Oh, come on, why do you always got to attack everything? Why can't we just try talking to it?
Joe Manganiello: Big surprise, Podcast here wants to talk.
Kareem Abdul-Jabbar: What do you think, Leonard?
Leonard: I think this is the greatest day of my entire life.
William Shatner: It's all right, buddy, one day you'll meet a girl.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Wil Wheaton: All right, Professor Proton fans, get ready to meet Dr. Sheldon Cooper and Dr. Amy Farrah Fowler, a pair of real-life scientists who may win the Nobel Prize. That's like the Kids' Choice Award, but with more science and less slime.

Sheldon: Kids' Choice Award? Why would they let kids choose anything? They're basically human larvae.
Wil Wheaton: Well, they are kind of our target audience.
Sheldon: Greetings, children. Toys, am I right?
Amy: He is. He has hundreds of them.

Wil Wheaton: So you two have discovered something that a lot of people are really excited about.
Amy: We have.
Wil Wheaton: Now, before you explain it, keep in mind that our average viewer is this many.