Leonard: But there is something I should prepare you for.
Mary Cooper: Oh, relax, Leonard. I have raised that boy. I have seen him at his best and I've seen him at his worst. There's nothing he can do that will surprise me.

Mary Cooper: Good morning, snickerdoodle. Well that looks awful fancy, what is that?
Sheldon: It's my idea of what DNA would look like in a silicon-based life-form.
Mary Cooper: But intelligently designed by a creator, right?

Sheldon: Leonard's mom is a renowned psychiatrist and woman of science. Can you please keep the Bible babble to yourself while she's here?
Mary Cooper: Are you ashamed of me?
Sheldon: Of course not. I love you. I'm just embarrassed by the things you believe, do and say.
Mary Cooper: Well, I love you, too, my little bowl of lion chow.

Mary Cooper: Do you wanna tell me what happened?
Sheldon: Are you gonna say it's all part of God's plan?
Mary Cooper: Good chance.

Howard: Forgive me for being so bold, but I now see where Sheldon gets his charming good looks.
Mary: Honey, that ain't gonna work, but you keep trying.

Mary: Thank you again for picking us up.
Raj: (chuckles) My pleasure, Mrs. Cooper.
Mary: You know, our driver to the airport was also a Indian fella.
Missy: Mom!
Mary: Oh, so now it's racist to notice when somebody's Indian.
Raj: I don't think it's racist. I noticed you were both white.
Mary: See?

Mary Cooper: Thank you, God, for the food we are about to receive and for the nourishment of our bodies and bless the hands that prepared it. Amen.
Sheldon: Given that your hands prepared it, isn't that a little self-serving?
Mary Cooper: You start changing the words to the prayers, next thing you know, you're in a church with a guitar.

Mary: Let me straighten your tie.
Sheldon: No, no, no, it's all right. It's supposed to be a little asymmetrical. Apparently, a small flaw somehow improves it.
Mary: I can see that. Sometimes it's the imperfect stuff that makes things perfect.
Sheldon: Excuse me. *Sheldon rushes out of the room*
Mary: Case in point.

Amy: Sheldon, what what are you doing?
Sheldon: Just being the un-socialized eccentric my mother always thought I was.
Mary Cooper: You startin' to see why I didn't go in there?

Leonard: Kung Fu letters might not be politically correct.
Mary Cooper: Oh, I thought the one we couldn't say was Ching-Chong.
Leonard: Yeah, that too.

Sheldon: Thanks for carving a smiley face in my grilled cheese sandwich.
Mary Cooper: Well, I know how to take care of my baby. His eyes came out a little thin, but you can just pretend he's Chinese.

Alfred Hofstadter: So, after your husband passed, you never remarried?
Mary Cooper: No, just focused on work and the church.
Alfred Hofstadter: Ah. And what do you do?
Mary Cooper: I work at the church.