Sheldon: (on Stephen Hawking's voice mail) I kiss girls now.

Sheldon: He has glasses and I'm a know-it-all. We are not built for prison.

Sheldon: Steven Hawking's a genius and he talks like a robot. It's everything I ever wanted in a friend.

Sheldon: I have one question. Is this a prank? Where you land in Houston and you've made up wanted posters which have my face with a moustache and a Spanish name, and I get arrested and deported to South America?
Howard: No.
Sheldon: Well I'm glad, because I would not have seen that coming.

Bernadette: Sheldon, when was the last time you got any sleep?
Sheldon: I don't know. 2 or 3 days. Not important. I don't need sleep, I need answers. I need to determine where in this swamp of unbalanced formulas squatteth the toad of truth.
Penny: Toad of truth? Is that a physics thing?
Leonard: No, that's a crazy thing.

Sheldon: Why hast thou forsaken me, O deity whose existence I doubt?

Amy: Oh. That's me. Hello? Yes, this is Dr. Fowler. I see. Okay, thank you. We won.
Penny: Congratulations!
Leonard: Oh, my God!
Sheldon: We did it.
Amy: I know. Can you believe it?
Sheldon: That's a good point. What if I'm dreaming? [Leonard slaps Sheldon] We won the Nobel Prize!

Sheldon: Oh, what fresh hell is this?

Leonard: That is not a compromise. A compromise is me driving you everywhere because you refuse to learn how.
Sheldon: Oh, I learned how. Amy taught me.
Leonard: What?! Then why don't you do it?
Sheldon: Well, it's scary, and sometimes I get the pedals mixed up. But more importantly, driving me to work is one of the things that gives your life purpose. I can't take that away from you, so what do I do? Come on, I'm practically feeding you the answer. I compromise.

Sheldon: I'm not a child. I know the word 'ninny.'

Howard: Listen, I was thinking you and I could probably try to be better friends.
Sheldon: Really? I was thinking what we have now is a bit much.

Sheldon: I didn't care for her yelling, but now that I'm not going to hear it again, I'm sad.
Leonard: If you want, I can yell at you later.
Sheldon: It won't be as good.

Sheldon: The National Science Foundation wants to give me a substantial grant.
Raj: That's a big deal.
Sheldon: I know. When will this nightmare end?

Koothrappali: Oh, great. No Superman, no Wonder Woman? All we've got is a skinny Flash, an Indian Aquaman, a near-sighted Green Lantern, and a teeny, tiny Dark Knight.
Sheldon: Obviously, we're no longer a Justice League. We have no choice but to switch to our Muppet Baby costumes.
Koothrappali: Ooh, I call Kermit.
Sheldon: I'm Kermit. You're Scooter.
Koothrappali: Oh, man. Scooter sucks. He's the Aquaman of the Muppet Babies.

Sheldon: (In Mandarin) Show me your mucus. Your mucus!
Chen: (Mandarin) Blow your own nose and go away!
Sheldon: (Mandarin) This is not a tangerine bicycle. Show me your mucus!
Chen: Crazy man. Call the police.
Sheldon: (Mandarin) No, don't call the library. Show me your mucus.