Mary Cooper: Shelly, how do I put this? By your third birthday, you had memorized over a thousand different kinds of trains, and I never imagined a woman getting aboard any of them.
Sheldon: What, so - You thought I was going to be alone for the rest of my life?
Mary Cooper: No! Just for the middle part. 'Cause at the end I assumed there'd be nurses.

Mary: He gets his temper from his daddy.
Leonard: Ah.
Mary: He's got my eyes.
Leonard: I see.
Mary: All that science stuff, that comes from Jesus.

Sheldon: Well, this is confusing for me. But I don't want to stand in the way of your happiness. So, I will condemn you internally while maintaining an outward appearance of acceptance.
Mary: That is very Christian of you.

Sheldon: I'd like you to meet Oppenheimer, Frisch, Panofsky, Feynman, Weisskopf.
Mary: Yeah, I get it. You got a lot of cats, and you gave 'em cute Jewish names.

Bernadette: Everyone's a better mom than me.
Raj: Oh, don't take it so personally, maybe your baby's just a jerk.

Amy: Well, uh, Howard and Bernadette had their baby.
Mary Cooper: (gasps) Oh, that's wonderful! Now, have they decided to raise it Jewish or regular?
Sheldon: Welcome to Texas.

Mary Cooper: Sheldon, if you're trying to prove me wrong, the tighty-whities on your head ain't changing my mind.