Mary Cooper: Shelly, how do I put this? By your third birthday, you had memorized over a thousand different kinds of trains, and I never imagined a woman getting aboard any of them.
Sheldon: What, so - You thought I was going to be alone for the rest of my life?
Mary Cooper: No! Just for the middle part. 'Cause at the end I assumed there'd be nurses.

Sheldon: Well, this is confusing for me. But I don't want to stand in the way of your happiness. So, I will condemn you internally while maintaining an outward appearance of acceptance.
Mary: That is very Christian of you.

Mary Cooper: So who else is coming to this shindig?
Amy: Oh, well, the usual gang. Penny's family is coming tomorrow.
Sheldon: Yeah, and Leonards mother's already here.
Mary Cooper: Oh. Beverly. How nice.
Amy: You've met her, right?
Mary Cooper: Yes, I have. (reveals her cross necklace)
Sheldon: Mother, she's an atheist, not a vampire.
Mary Cooper: Either way, let's stop and get some garlic.

Mary Cooper: Raj is it? Still having trouble talking to the ladies? Because you know at our church we have a woman who's an amazing healer. Mainly she does crutch and wheelchair people. But I bet she'd be willing to take a shot at whatever third-world demon is running around inside of you.

Amy: Well, uh, Howard and Bernadette had their baby.
Mary Cooper: (gasps) Oh, that's wonderful! Now, have they decided to raise it Jewish or regular?
Sheldon: Welcome to Texas.

Bernadette: Everyone's a better mom than me.
Raj: Oh, don't take it so personally, maybe your baby's just a jerk.

Mary Cooper: Sheldon, if you're trying to prove me wrong, the tighty-whities on your head ain't changing my mind.