Amy: Why didn't you tell me?
Bernadette: We didn't want you to worry.
Amy: Should I worry?
Penny: No, come on, it's Sheldon. Nothing is gonna happen.
Amy: That's what you said to me when I started dating him. And then five years later, bingo-bango, something happened.

Sheldon: Oh, Amy. Good, you're here.
Amy: Hi. What's up?
Sheldon: How would you like to be on television?
Amy: Is it gonna be a news story where I have to say you were quiet and kept to yourself and I'm as shocked as anyone?

Sheldon: Can I get you anything else?
Amy: No, thanks. I think I'm good.
Sheldon: You sure? There's still plenty of pork fat. Although, if we don't eat it, I suppose we could turn it into soap.
Amy: That might taste better.

Sheldon: Did Bernadette even try to send us a sewing kit?
Amy: She did. Amazon, standard shipping, not even Prime.
Sheldon: (gasps) We could've done that ourselves.
Amy: (chuckles) That's what she said.

Penny: Look, I know this is your wedding, and you can do whatever you want, but if you think anyone but me is gonna be your maid of honor, then you're an idiot because you are my best friend.
Howard: Too late, Bernade-
Amy: (pushes Howard out of the way, rushes to hug Penny) Bestie!

Penny: Where does Sheldon think you are?
Amy: Oh, Sheldon's kind of like a dog, he doesn't really think about me when I'm gone, but he's so happy when I show up.

Amy: Wow. Déjà vu.
Sheldon: Amy, you're a neuroscientist. you know the latest research into déjà vu suggests it's nothing but the frontal regions of the brain attempting to correct an inaccurate memory.
Amy: You telling me stuff I already know is definitely déjà vu.

Sheldon: How can I tell if I'm doing something for a noble reason or a selfish reason?
Amy: Try saying the thing in your head and see if you can add the words, "That'll show 'em."

Amy: You can't blame yourself. When your pre-frontal cortex fails to make you happy, promiscuity rewards you with the needed flood of Dopamine. We neurobiologists refer to it as the skank reflex.

Amy: (Reading Sheldon's relationship agreement) Section 5, Hand Holding: Hand holding is only allowed under the following circumstances: A. either party is in danger of falling of a cliff, precipice or ledge; B. either party is deserving of a hearty hand shake after winning a Nobel prize; C. moral support during flu shots.

Amy: I find the notion of romantic love an unnecessary cultural construct that adds no value to human relationships.

Penny: Coming. Yup, that's good. Wine glasses should have handles. (Answers the door to Amy)
Amy: Keeping accurate track of your alcohol intake. Smart idea considering how trampy you get when you've had a few.
Penny: You heard what I did?
Amy: I heard who you did.

Amy: Sheldon, is it possible that your foul mood -- or, to use the clinical term, bitchiness -- is because your mother isn't making you a priority?
Sheldon: No. Or, to use the clinical term: "nuh-uh."

Amy: You don't need to explain yourself to him.
Sheldon: (To Leonard) I don't need to explain myself to you!
Amy: You're sick of his nonsense and you're ready to move in with me.
Sheldon: (To Leonard) Keep the table. We don't use that space.
Amy: Damn it. I got cocky.

Amy: Oh, are we nervous, Dr. Cooper?
Sheldon: No. What you see is a man trembling with confidence.