Leonard: You went to the comic book store by yourself?
Penny: Yeah, it was fun. I walked in and two different guys got asthma attacks. It felt pretty good.

Leonard: Once you open the box it loses its value.
Penny: Yeah, yeah. My mom gave me the same lecture about my virginity. I gotta tell you, it was a lot more fun taking it out and playing with it.

Amy: I'm dating Sheldon Cooper
Penny: Yes. On purpose.
Amy: He's handsome, he's lanky, he's brilliant, and his skin has that pale, waxy quality.
Penny: Well, sickly is the new sexy.

Penny: Sorry, Stallion. Your weird friend Giraffe is here.

Amy: That would be my boyfriend. Happier playing his dopey Star Trek game with his friends than hanging out with me
Penny: Wars.
Amy: What?
Penny: Star Wars. They get all cranky when you mix the two up.
Amy: What's the difference?
Penny: There is absolutely no difference!

Penny: You can't put a saddle on Leonard Hofstadter. Oh, my, is it getting hot in here? Ay, papi.
Leonard: Ay papi? What is that?
Penny: An acting choice.
Leonard: Oh. So you chose that when you become turned on, you turn into Speedy Gonzalez?
Penny: Choo got a problem with that, papi?

Sheldon: Oh, come on. It's just a simple favor. Now, when's the last time I asked you to do something for me?
Penny: Yesterday. You made me look in your ear to see if there was a ladybug in it.
Sheldon: When is the last time I asked you to do something that wasn't a medical emergency?
Penny: Yesterday. You made me look in your ear to see if there was a ladybug in it.

Penny: Amy, what's wrong?
Amy: My boyfriend's a jerk.
Penny: Well, I know he didn't cheat on you, so what happened?

Penny: You know, Amy, sometimes when you're in a relationship with someone you really care about, the sucky part is, it leaves you open to getting hurt.
Amy: Do you ever worry about Leonard doing that to you?
Penny: That's hilarious. No.

Penny: All right, then we're gonna have to go with an oldie but goodie, making a scene.
Amy: I don't think I'd be good at that.
Penny: That's why you're lucky to have me. Back in Omaha, there are two different restaurants I'm not allowed into. Both Chili's.

Penny: Sheldon, she wanted to show you off to her family, and you stood her up, okay? Look at this adorable, smushy face. Smush, smush, smush, smush.
Amy: You're hurting me.
Penny: No, Sheldon hurt you.
Amy: Before; now it's you.
Penny: Oh.

Penny: And that's how a girl makes a scene. I'm sorry, sweetie. You're right. You deserve your weekend. Come on, Amy, let's go.
Amy: What about the Science Center?
Penny: I'll let you hold my hair while I throw up.

Penny: All right, Sheldon, this craziness has gone on long enough. Please come home so I can cut your hair.
Sheldon: Penny, you're not trained. You're not licensed. Most importantly, you don't have access to my haircut records.
Penny: All right, honey, look, we've known each other for a long time now, right? I've taken you to Disneyland, I kicked a bully in the nuts for you, I sing you Soft Kitty when you're sick. You even saw me naked once.
Leonard: I'm sorry. Uh, what?
Penny: It was a long story. Anyway, Sheldon, I promise I know what I'm doing. Please let me cut your hair.

Bernadette: (Looking at the painting Amy bought Penny) That is big.
Penny: So big.
Bernadette: And ugly.
Penny: So ugly.

Penny: Hey, what are you guys doing here?
Howard: We're grown men, we drink at bars.
Penny: No and no. Everything okay with you and Bernadette?
Howard: Oh yeah, sure.
Penny: You and Amy? Good?
Sheldon: Oh, better than good.
Penny: You know those girls text me every detail of their lives as it happens.