Leonard: How many times do I have to tell you, I have no interest in this woman.
Penny: Yeah, well maybe she has interest in you.
Sheldon: In Leonard? Oh, even the Sparkletts guy could see that's unlikely.

Leonard: I still don't understand why you bought that pill caddie. You're a young man.
Sheldon: Age is a state of mind, Leonard. In here I'm 90.

Sheldon: I smell funny. I taste salty.
Leonard: You're just sweaty from exercise.
Sheldon: And kind of delicious. I wonder how many licks it would take to get to the center of me.
Leonard: I know it only takes one doctor's finger.

Amy: Hi, Sheldon. What's up?
Sheldon: Well, I'm calling because Thanksgiving is coming up, and I wanted to offer you the aquarium tickets.
Amy: No one can go with you?
Sheldon: No. They'd rather spend the holiday with each other than find out if this is the year I finally touch a starfish.

Sheldon: Do you have any questions for me?
Amy: Just one. Are you doing okay?
Sheldon: I am.
Amy: Good. I want you to be happy.
Sheldon: I believe you. I'd believe you more if you threw a few Apple Jacks in here.

Sheldon: Thank you, Arthur. You are the wisest of the wise.
Professor Proton: Well, that's very nice of you to say, but I think I'm just an expression of your unconscious mind.
Sheldon: Oh, sure. Well, you're fun to look at.

Penny: Yeah, the last time I got a hand written letter, it was from someone who told me I parked like a blind person.
Leonard: That someone has a name.
Sheldon: Uh, thank you.

Leonard: Hey, Raj, I read a couple guys in your department may have discovered a new planet in our solar system?
Sheldon: Oh, I heard about that. Why didn't you discover it?
Raj: Because instead of being in the telescope room, I was busy making you guys homemade jam for the holidays.
Sheldon: Well, you be sure to let us know when you win the Nobel Prize for boysenberry

Penny: Okay, while they get the cake, Sheldon, I just want to say, I hope you didn't think you were gonna get through tonight without a hug.
Sheldon: You know, I used to hate these hugs. Now they're just extremely irritating.

Sheldon: Amy and I are living together in sin, like a couple of New Yorkers. Now, while you scold us, I'm going to get a knife and a fork. Joe may be sloppy, but Sheldon's not.

Penny: Okay, let's try this. Think of yourself as one of those limited edition toys people like to collect.
Sheldon: I already do.

Sheldon: Like a milking stool, my case rests on three legs. I will demonstrate that I was improperly instructed in driving by a woman whose lack of respect for society borders on the sociopathic. I will argue that the emergency met the legal doctrine of quod est necessarium est licitum, that which is necessary is legal. But first, I will raise a Sixth Amendment issue. I'm unable to confront my accuser, a non-human entity, to wit, a camera. So, to sum up, improper instruction, quod est necessarium est licitum, Sixth Amendment. My milk stool is complete.

President Siebert: You know, Caltech has 38 Nobel laureates. If you win, you and Amy will be 39 and 40.
Sheldon: Ooh! Dibs on 39.
Amy: What's the difference?
Sheldon: Wha- You are right, there is no difference at all.

Sheldon: (On the phone) This is Dr. Sheldon Cooper. Yeah, I need to cancel my membership to the planetarium. Yeah, well, I'm sorry too, but there's just no room for you in my wallet. No, I understand, but it was between you and the Museum of Natural History, and frankly, you don't have dinosaurs. Oh, I'll miss you too. Bye-bye.

Sheldon: All right, so the topic at hand is sexual fidelity. Probably won't be relying on Suess here. Although One Fish Two Fish, Red Fish Blue Fish might be surprisingly applicable here.