Leonard: Are you set on people laughing WITH you? Because if you're cool with AT you ...
Sheldon: I don't get it.

Sheldon: Koko learned to understands over 2000 words, not one of which had anything to do with shoes.

Sheldon: (Running from the angry mob) Why is there never a pontoon plane when you need one?

Kripke: I'm Barry Kripke and I'm here because you told me there was a raffle. Where is the raffle?
Sheldon: Patience, patience, Barry, the waffle-- ahem. The raffle... is the grand finale to an evening-long festival of fun and folly.
Kripke: One more question--
Sheldon: Yes, you must be present to win.

Sheldon: Goodnight puny human!

Amy: Well, for starters, there's nothing wrong with keeping our toothbrushes in the same holder.
Penny: Sheldon, what do you say to that?
Sheldon: I think we should see other people.

Leonard: Maybe you should consider women who aren't in serious relationships with your closest friends?
Sheldon: There's that prostate doctor, but I'm still mad at her.

Howard: You're either on Team Leonard or Team Penny.
Sheldon: Which one picks last?
Howard: What?
Sheldon: Well, usually I'm on the team that picks last. Unless there's a kid in the wheelchair.

Adam Nimoy: What was it about Spock that appealed to you?
Sheldon: I think the same thing that appeals to people everywhere, the dream of a cold, rational world entirely without human emotion.
Spock came from a planet governed only by logic.
You know, on Vulcan, when your brother asks, "Why are you hitting yourself?" The answer is, "I'm not. You're moving my arm." To which he says, "fascinating." And then you both watch educational television.

Sheldon: First, talking to you while you're on the toilet isn't exactly a picnic for me either. Remember, when you can hear me, I can hear you.

Sheldon: Hello?
Leonard: Oh, hey, where you been? We've been calling you for hours.
Sheldon: Oh, I'm sorry, my phone was on "airplane" mode.
Leonard: Why?
Sheldon: Because I was on an airplane. (makes confused gesture to Amy)

Penny: That's so funny. I never would have pegged you for a Pisces.
Sheldon: You're making it difficult to love you right now.

Sheldon: You know what? Let me give you a better question. Here, um, "Dr. Cooper, "I heard you were working on a top-secret project "for the U.S. military. Why don't you tell us about that?" See, that's a great question.
Dr. Harris: Okay, what was that like?
Sheldon: Oh, I can't tell you that, it's top-secret.

Sheldon: So, did you defile my mother or not?

Penny: Yeah, the last time I got a hand written letter, it was from someone who told me I parked like a blind person.
Leonard: That someone has a name.
Sheldon: Uh, thank you.