Howard: What can I tell you? After I found the courage to put her pants back on, I was unstoppable.

Howard: What you've got to keep in mind is that ever since my dad left, I've been the whole world to my mother. I mean, she'd be threatened by any woman who can give me what she can't.
Bernadette: You mean sexual intercourse?
Howard: Well, when you say it like that you make it sound creepy.

Raj: You'd think it'd be because my parents didn't love me, but actually they loved me a great deal.
Howard: Bernie, it's not you. She's just set in her ways.
Bernadette: How can we be together if the thought of us getting married might kill your mother?
Howard: It's the circle of life, sweetie. One day our son will marry someone and it will kill you.

Doctor: You brought a Catholic girl home to your mother?
Howard: Yeah.
Doctor: Why don't I write you a prescription for Xanax.

Howard: Is it just me, or does she sound sexy when she's angry?

Sheldon: It's like I'm living in a dictatorship. You must take a vacation, you must have fun, you must enjoy life.
Howard: I don't think you have a good handle on dictatorships.

Howard: Bernadette's going to be playing with us. So, that's pretty cool, huh? Right? Sure it is, yeah.
Raj: What, you invited your girlfriend? This is supposed to be our weekend.
Howard: I had no choice. Last night, she said, why don't we go out for brunch tomorrow and then maybe the Arboretum. And I said, well, no, I promised the guys I was going to play a video game with them all weekend. And she said, that sounds like fun, can I come, too? And then I didn't answer for a second, and then she said, well, do you not want me to come? And then I bought her a new laptop and the game, and she's parking the car right now.

Howard: This isn't the reaction I expected when I told you I was gonna be an astronaut.
Bernadette: What did you think was going to happen?
Howard: Honestly? Sex.
Bernadette: Howard!

Raj: So, what's gonna happen next? Are you and Bernadette going to break up?
Howard: I don't know. If we're going to get back together, she's going to have to apologize and accept that I'm a grown man who can make his own decisions.
Raj: Then she's going to have to convince your mother to let you go into space.
Howard: Obviously.

Howard: If you're gonna love me, you're gonna have to love the whole package, the tenderhearted poet and the crazy daredevil.
Bernadette: I know.
Howard: Well, don't say it if you're not gonna mean it, 'cause I'm not just gonna stop with the space station. Yeah, I want to go to the Moon, I want to go to Mars. I want to take a one-man sub to the lowest depths of the ocean.
Bernadette: Really? You got seasick on Pirates of the Caribbean.
Howard: Well, those big kids were rocking it.

Howard: You know, Sheldon, you don't have so many friends that you can afford to start insulting them.

Howard: The only thing we need to do is make this Kim kid lose his focus.
Leonard: That won't happen, he's not interested in anything but physics.
Howard: What about biology?
Leonard: What?
Howard: You know, biology? The one thing that can completely derail a world class mind.

Leonard: Howard, he's fifteen.
Howard: Yeah, so, when I was fifteen I met Denise Palmeri and my grade point average fell from a 5.0 to a 1.8.
Raj: She was sleeping with you?
Howard: No, I just wasted a lot of time thinking about what it would be like if she did.

Howard: Well, congratulations. I'm so happy for you two. Hold on, I have to tell Bernadette. Hey, Bernie, guess what? Sheldon and Amy got engaged. Can you believe it?
Bernadette: (In the bathroom with a pregnancy test) Oh, my God. I cannot believe it.
Howard: She's so happy I think she's crying.

Howard: Hey. Want me to make dinner?
Bernadette: Uh, sure, but first, why don't you have a seat? There's something I need to show you.
Howard: Ooh, if it's how to make dinner, that'd be great.