Penny: I think I caught the flu. *Throwing up*. Or the plague!

Leonard: A long time ago, I made a deal with Howard involving you.
Penny: Okay, I don't know where this is going, but tread carefully, because this may be the last conversation we ever have.

Penny: I can't believe it. if I hadn't been working the dinner shift, I would've run right into the robbers.
Leonard: Hey, there's no reason for you to be scared.
Penny: I'm not scared. I would've gone all Nebraska on their asses.

Sheldon: I don't think I can go back out there.
Penny: That's fine. You know, I hate that your sister and her friends used to torture you. But what I hate even more is, if I was there, I would have tortured you, too.
Sheldon: Based on this pep talk, I'd say you're still doing it.
Penny: My point is, there was a time I never would've been friends with someone like you, and now you are one of my favorite people. So, if what you need is to spend your birthday in a bathroom, I'm happy to do it with you.
Sheldon: Well, everyone will think I'm weird.
Penny: Sweetie, you are weird. Everyone knows you're weird, but they're all still here because they care about you so much.

Leonard: It seems a shame to throw it away.
Penny: Yeah. We could give it to Sheldon and tell him William Shatner painted it.
Leonard: God, I love you. I love you so much.

Penny: Not really a great outfit for work. Unless something opens up in the Hookers & Whores department.

Raj: Don't come to the hospital. We're headed home.
Penny: Oh, that was fast. Did she sneeze the baby out?

Sheldon: Do you think your father's doing unspeakable things to my mother?
Leonard: No.
Sheldon: Are you saying that because the things are unspeakable?
Penny: Your parents are old. Anything unspeakable was finished by 9:30.

Penny: Hey, since when do you do laundry on a Thursday?
Sheldon: Oh, I had an accident at work, I slipped and fell on my soup sack.
Penny: You know, there was a time I would say "What's a soup sack?" But I'm glad we're past that.

Sheldon: I don't know what the protocol is here. Do I stay, do I leave? Do I wait to greet them with a refreshing beverage?
Penny: Gee, Sheldon, you're asking the wrong girl. I'm usually on the other side of the tie.

Bernadette: Yeah, it's your third date, maybe you could go more sexy.
Amy: Well, some people think the sexiest organ is the brain.
Penny: No one ever bought me drinks at a bar because my brain just popped out of my shirt.

Amy: You wouldn't be dating Penny.
Leonard: You don't know that. I've been going to the Cheesecake Factory for years. I could have picked her up.
*Everybody laughs*
Penny: Oh, you weren't joking?

Penny: Come on, we are not old, boring people. We can do better than this.
Leonard: That's true. How late did we stay up last night?
Penny: Almost 1 am.
Leonard: Damn straight almost 1 am. And we weren't even watching TV, we were watching Netflix like the kids do.
Penny: Yeah. Is it a comedy, is it a drama? Nobody knows!

Penny: What up, Shel-bot?

Penny: And this is also not the right time. Do not propose.
Leonard: What?!
Penny: I know that face. That's your proposed face.